Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 6/20 | 0.55 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 3/20 | 0.33 |
| ▸ | CES1 | P23141 | 3/20 | 0.33 |
| ▸ | PPARG | P37231 | 3/20 | 0.33 |
| ▸ | PPARD | Q03181 | 3/20 | 0.33 |
| ▸ | PPARA | Q07869 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.33 |
| ▸ | TLR2 | O60603 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17277148 | 0.87 | APEX1 (0.57) | APEX1DNM1THRBCES2CES1 | |
| SCHEMBL17689291 | 0.84 | APEX1 (0.75) | APEX1PPARGPPARDPPARATSHR | |
| SCHEMBL17277149 | 0.79 | APEX1 (0.44) | APEX1 | |
| SCHEMBL14135165 | 0.79 | APEX1 (0.53) | APEX1TDP1ALDH1A1 | |
| SCHEMBL17833998 | 0.79 | APEX1 (0.53) | APEX1TDP1ALDH1A1 | |
| SCHEMBL17277627 | 0.77 | APEX1 (0.72) | APEX1DNM1THRBTDP1ALDH1A1 | |
| SCHEMBL17689292 | 0.76 | APEX1 (0.57) | APEX1THRBCES2CES1TDP1 | |
| Apx-3330 SCHEMBL3758719 | 0.71 | APEX1 (1.00) | APEX1THRBPPARGTSHRGPR84 | |
| Apx-3330 SCHEMBL3758716 | 0.71 | APEX1 (1.00) | APEX1THRBPPARGTSHRGPR84 | |
| SCHEMBL15705626 | 0.71 | APEX1 (0.70) | APEX1THRBTDP1ALDH1A1PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9315481-B2 | Compounds and methods for treating leukemia | INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION (US) | 2016-04-19 | — | — | US | disclosed |