Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 10/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 8/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.39 |
| ▸ | PIM1 | P11309 | 4/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.34 |
| ▸ | BMI1 | P35226 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2145153 | 0.89 | JAK2 (0.44) | JAK2JAK1JAK3PTK2PIM1 | |
| SCHEMBL2145150 | 0.89 | JAK2 (0.44) | JAK2JAK1JAK3PTK2PIM1 | |
| SCHEMBL2145147 | 0.89 | JAK2 (0.44) | JAK2JAK1JAK3PTK2PIM1 | |
| SCHEMBL3305993 | 0.88 | JAK2 (0.41) | JAK2JAK1JAK3PTK2SCN9A | |
| SCHEMBL3305999 | 0.88 | JAK2 (0.41) | JAK2JAK1JAK3PTK2SCN9A | |
| SCHEMBL13391951 | 0.88 | JAK2 (0.44) | JAK2JAK1JAK3PTK2PIM1 | |
| SCHEMBL17685406 | 0.86 | JAK2 (0.41) | JAK2JAK1JAK3PTK2PIM1 | |
| SCHEMBL2144131 | 0.85 | JAK2 (0.44) | JAK2JAK1JAK3PTK2SCN9A | |
| SCHEMBL2144135 | 0.85 | JAK2 (0.44) | JAK2JAK1JAK3PTK2SCN9A | |
| SCHEMBL2144458 | 0.85 | JAK2 (0.44) | JAK2JAK1JAK3PTK2SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344494-B1 | AMINOTRIAZOLOPYRIDINES AND THEIR USE AS KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2016-04-20 | — | — | EP | disclosed |