Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Glyceryl Monostearate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | DGKA | P23743 | 1/20 | 0.64 |
| ▸ | FAAH | O00519 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.51 |
| ▸ | PRKCA | P17252 | 3/20 | 0.51 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.51 |
| ▸ | LPAR6 | P43657 | 1/20 | 0.51 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.51 |
| ▸ | LPAR4 | Q99677 | 1/20 | 0.51 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.51 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.51 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glyceryl Monostearate SCHEMBL99649 | 1.00 | KDM4E (0.74) | KDM4EDUSP3MEN1KMT2ALMNA | |
| Citric Acid SCHEMBL28491671 | 1.00 | KDM4E (0.74) | KDM4EDUSP3MEN1KMT2ALMNA | |
| Citric Acid SCHEMBL28484232 | 1.00 | KDM4E (0.74) | KDM4EDUSP3MEN1KMT2ALMNA | |
| Glyceryl Monostearate SCHEMBL27824217 | 1.00 | KDM4E (0.74) | KDM4EDUSP3MEN1KMT2ALMNA | |
| Glyceryl Monostearate SCHEMBL5969653 | 1.00 | KDM4E (0.74) | KDM4EDUSP3MEN1KMT2ALMNA | |
| Glyceryl Monostearate SCHEMBL21808821 | 1.00 | KDM4E (0.74) | KDM4EDUSP3MEN1KMT2ALMNA | |
| Glycerol Monolaurate SCHEMBL650317 | 1.00 | KDM4E (0.74) | KDM4EDUSP3MEN1KMT2ALMNA | |
| Glyceryl Monostearate SCHEMBL5574849 | 1.00 | KDM4E (0.74) | KDM4EDUSP3MEN1KMT2ALMNA | |
| Glyceryl Monostearate SCHEMBL6652800 | 1.00 | KDM4E (0.74) | KDM4EDUSP3MEN1KMT2ALMNA | |
| Glyceryl Monostearate SCHEMBL7129355 | 0.99 | KDM4E (0.72) | KDM4EDUSP3MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3658112-A1 | ACTIVE SUBSTANCE COMBINATIONS OF N-(4-AMINO-2-METHYLQUINOLINE-6-YL)-2-((4-ETHYLPHENOXY)METHYL) AND ONE OR MORE COSMETICALLY OR DERMATOLOGICALLY ACCEPTABLE PRESERVATIVES AND/OR PRESERVATIVE AUXILIARIES | Beiersdorf AG (DE) | 2020-06-03 | — | — | EP | disclosed |
| EP-2501360-A1 | TETRAPEPTIDES FOR BRIGHTENING THE SKIN | Evonik Goldschmidt GmbH (DE) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011061024-A1 | TETRAPEPTIDES FOR BRIGHTENING THE SKIN | EVONIK GOLDSCHMIDT GMBH (DE) | 2011-05-26 | — | — | WO | disclosed |