Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.74 |
| ▸ | GSK3B | P49841 | 2/20 | 0.74 |
| ▸ | TNKS2 | Q9H2K2 | 7/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | TNKS | O95271 | 4/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | TP53 | P04637 | 4/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | SULT2A1 | Q06520 | 1/20 | 0.58 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.58 |
| ▸ | AXIN2 | Q9Y2T1 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17695683 | 0.90 | GSK3B (0.91) | GSK3AGSK3BMAPTSMN1; SMN2NPC1 | |
| SCHEMBL17695674 | 0.86 | GSK3B (0.76) | GSK3AGSK3BMAPTSMN1; SMN2NPC1 | |
| SCHEMBL17695642 | 0.86 | GSK3B (0.79) | GSK3AGSK3BMAPTSMN1; SMN2NPC1 | |
| SCHEMBL17695670 | 0.86 | GSK3B (0.79) | GSK3AGSK3BMAPTSMN1; SMN2NPC1 | |
| SCHEMBL17695651 | 0.86 | GSK3B (0.95) | GSK3AGSK3BTNKS2MAPTSMN1; SMN2 | |
| SCHEMBL17695678 | 0.85 | GSK3B (1.00) | GSK3AGSK3BTNKS2MAPTSMN1; SMN2 | |
| SCHEMBL17695650 | 0.85 | GSK3B (0.74) | GSK3AGSK3BMAPTSMN1; SMN2NPC1 | |
| SCHEMBL17695666 | 0.83 | GSK3B (0.72) | GSK3AGSK3BMAPTSMN1; SMN2NPC1 | |
| SCHEMBL17695627 | 0.83 | GSK3B (0.71) | GSK3AGSK3BTNKS2MAPTSMN1; SMN2 | |
| SCHEMBL17695659 | 0.83 | GSK3B (0.74) | GSK3AGSK3BMAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016061344-A1 | GSK3 INHIBITORS AND THEIR USES | MIRX PHARMACEUTICALS LLC (US) | 2016-04-21 | — | — | WO | disclosed |