Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 20/20 | 0.74 |
| ▸ | CXCR1 | P25024 | 19/20 | 0.74 |
| ▸ | CCR7 | P32248 | 4/20 | 0.74 |
| ▸ | CCR6 | P51684 | 2/20 | 0.61 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.61 |
| ▸ | CCR4 | P51679 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14905958 | 0.90 | CXCR2 (0.77) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL17698423 | 0.87 | CXCR1 (0.70) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL12262746 | 0.86 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL14894938 | 0.85 | CXCR1 (0.84) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL12262779 | 0.84 | CXCR1 (0.93) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL14905897 | 0.84 | CXCR2 (0.70) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL17004517 | 0.83 | CXCR1 (0.71) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL14894600 | 0.83 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL14895104 | 0.82 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6CXCR3 | |
| SCHEMBL21297010 | 0.82 | CXCR2 (1.00) | CXCR2CXCR1CCR7CCR6CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2771336-B1 | NOVEL DISUBSTITUTED 3,4-DIAMINO-3-CYCLOBUTENE-1,2-DIONE COMPOUNDS FOR USE IN THE TREATMENT OF CHEMOKINE-MEDIATED DISEASES | GALDERMA RES & DEV (FR) | 2016-04-27 | — | — | EP | claimed |