⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1770152 | 0.87 | — | — | |
| SCHEMBL1770184 | 0.79 | PLK4 (0.35) | — | |
| SCHEMBL27111321 | 0.79 | PLK4 (0.35) | — | |
| SCHEMBL7861521 | 0.78 | HIF1A (0.34) | — | |
| SCHEMBL7859383 | 0.78 | HIF1A (0.34) | — | |
| SCHEMBL7859385 | 0.78 | HIF1A (0.34) | — | |
| SCHEMBL11673290 | 0.76 | — | — | |
| SCHEMBL18725175 | 0.76 | — | — | |
| SCHEMBL16275210 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL9710685 | 0.74 | PLK4 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3831372-A1 | MITOGUAZONE FOR PREVENTING THE RELAPSE OR THE PROGRESSION OF MULTIPLE SCLEROSIS | Pathologica LLC (US) | 2021-06-09 | — | — | EP | disclosed |
| US-20210085625-A1 | CONTROLLED RELEASE ORAL PHARMACEUTICAL DOSAGE FORMS COMPRISING MGBG | PATHOLOGICA LLC | 2021-03-25 | — | — | US | disclosed |
| US-10881626-B2 | Controlled release oral pharmaceutical dosage forms comprising MGBG | PATHOLOGICA LLC (US) | 2021-01-05 | — | — | US | disclosed |
| US-20190224144-A1 | METHOD OF TREATMENT WITH ANTI-INFLAMMATORY AND ANALGESIC COMPOUNDS WHICH ARE GI-, RENAL-, AND PLATELET-SPARING | PATHOLOGICA LLC | 2019-07-25 | — | — | US | disclosed |
| US-10350178-B2 | Methods and compositions for treatment of demyelinating diseases | PATHOLOGICA LLC (US) | 2019-07-16 | — | — | US | disclosed |
| US-10292950-B2 | Method of treatment with anti-inflammatory and analgesic compounds which are GI-, renal-, and platelet-sparing | PATHOLOGICA LLC (US) | 2019-05-21 | — | — | US | disclosed |
| EP-3473247-A1 | COMPOSITION FOR ORAL DELIVERY COMPRISING MGBG FOR USE IN TREATING MULTIPLE SCLEROSIS | Pathologica LLC (US) | 2019-04-24 | — | — | EP | disclosed |
| US-20180369170-A1 | METHOD OF TREATMENT WITH ANTI-INFLAMMATORY AND ANALGESIC COMPOUNDS WHICH ARE GI-, RENAL-, AND PLATELET-SPARING | PATHOLOGICA LLC | 2018-12-27 | — | — | US | disclosed |
| US-20180360783-A1 | METHODS AND COMPOSITIONS FOR TREATMENT OF DEMYELINATING DISEASES | PATHOLOGICA LLC | 2018-12-20 | — | — | US | disclosed |
| EP-2453886-B1 | PHARMACEUTICAL FOR ORAL DELIVERY COMPRISING MGBG AND METHODS OF TREATING DISEASE | PATHOLOGICA LLC (US) | 2018-12-12 | — | — | EP | disclosed |
| US-20140187643-A1 | Method of Treatment with Anti-Inflammatory and Analgesic Compounds Which are GI-, Renal-, and Platelet-Sparing | PATHOLOGICA LLC (US) | 2014-07-03 | — | — | US | disclosed |
| US-20140051765-A1 | PHARMACEUTICAL FOR ORAL DELIVERY COMPRISING MGBG AND METHODS OF TREATING DISEASE | PATHOLOGICA LLC (US) | 2014-02-20 | — | — | US | disclosed |
| US-8609734-B2 | Methods of treating pain with MGBG | Pathdogica, LLC (US) | 2013-12-17 | — | — | US | disclosed |
| US-20130317113-A1 | REGULATION OF OSTEOPONTIN | PATHOLOGICA LLC (US) | 2013-11-28 | — | — | US | disclosed |
| US-8445540-B2 | Decreasing the activity of osteopontin in a cell comprising contacting the cell with an agent which inhibits S-adenosyl methionine decarboxylase, inhibits polyamine biosynthesis, or increases adenosine; MGBG, MDL73811, CGP48664, Berenil, Pentamidine, SL47, and/or SL93; autoimmune diseases; antitumor; HIV | PATHOLOGICA LLC (US) | 2013-05-21 | — | — | US | disclosed |
| US-20120289604-A1 | PHARMACEUTICAL FOR ORAL DELIVERY COMPRISING MGBG AND METHODS OF TREATING DISEASE | PATHOLOGICA LLC (US) | 2012-11-15 | — | — | US | disclosed |
| US-20120269891-A1 | CONTROLLED RELEASE ORAL PHARMACEUTICAL DOSAGE FORMS COMPRISING MGBG | PATHOLOGICA LLC (US) | 2012-10-25 | — | — | US | disclosed |
| US-8258186-B2 | Pharmaceutical for oral delivery comprising MGBG | PATHOLOGICA, LLC (US) | 2012-09-04 | — | — | US | disclosed |
| US-20110112199-A1 | PHARMACEUTICAL FOR ORAL DELIVERY COMPRISING MGBG AND METHODS OF TREATING DISEASE | PATHOLOGICA LLC (US) | 2011-05-12 | — | — | US | disclosed |
| US-20080262092-A1 | REGULATION OF OSTEOPONTIN | PATHOLOGICA LLC. (US) | 2008-10-23 | — | — | US | disclosed |