Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.41 |
| ▸ | F10 | P00742 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1770887 | 0.92 | MAPK1 (0.52) | MAPK1HPGDALDH1A1CASP1POLB | |
| SCHEMBL1770888 | 0.92 | MAPK1 (0.52) | MAPK1HPGDALDH1A1CASP1POLB | |
| Hydrochloric Acid SCHEMBL29197847 | 0.91 | MAPK1 (0.51) | MAPK1HPGDALDH1A1CASP1POLB | |
| SCHEMBL1770707 | 0.75 | MAPK1 (0.43) | MAPK1HPGDALDH1A1CASP1POLB | |
| SCHEMBL1770705 | 0.75 | MAPK1 (0.43) | MAPK1HPGDALDH1A1CASP1POLB | |
| SCHEMBL8280724 | 0.74 | MAPK1 (0.59) | MAPK1HPGDTSHRNPSR1F10 | |
| SCHEMBL5624977 | 0.73 | MAPK1 (0.51) | MAPK1HPGDHDAC4HDAC1HDAC6 | |
| SCHEMBL27691759 | 0.73 | MAPK1 (0.55) | MAPK1HPGDALDH1A1CASP1TSHR | |
| SCHEMBL15203328 | 0.73 | MAPK1 (0.55) | MAPK1HPGDALDH1A1CASP1HDAC4 | |
| SCHEMBL28801511 | 0.73 | MAPK1 (0.57) | MAPK1HPGDALDH1A1CASP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8378092-B2 | Chlorothiophene-amides as inhibitors of coagulation factors Xa and thrombin | SANOFI (FR) | 2013-02-19 | — | — | US | disclosed |
| EP-2254881-B1 | CHLOROTHIOPHENE-AMIDES AS INHIBITORS OF COAGULATION FACTORS XA AND THROMBIN | SANOFI SA (FR) | 2012-09-12 | — | — | EP | disclosed |
| US-20110112075-A1 | CHLOROTHIOPHENE-AMIDES AS INHIBITORS OF COAGULATION FACTORS XA AND THROMBIN | SANOFI-AVENTIS (FR) | 2011-05-12 | — | — | US | disclosed |
| EP-2254881-A1 | CHLOROTHIOPHENE-AMIDES AS INHIBITORS OF COAGULATION FACTORS XA AND THROMBIN | Sanofi-Aventis (FR) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009103440-A1 | CHLOROTHIOPHENE-AMIDES AS INHIBITORS OF COAGULATION FACTORS XA AND THROMBIN | SANOFI-AVENTIS (FR) | 2009-08-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112075-A1 | CHLOROTHIOPHENE-AMIDES AS INHIBITORS OF COAGULATION FACTORS XA AND THROMBIN | F12, F3, F2 | MAPK1 3632/4885HPGD 2830/4885ALDH1A1 2562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.