SCHEMBL17718954

SCHEMBL17718954

N#Cc1cccc(C(=O)N2CCN(Cc3c(-c4ccc(Cl)cc4)nc4ccc(-c5ccccc5)cn34)CC2)c1

nearest known ligand 0.81

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ SLC2A1 P11166 15/20 0.81
▸ KCNK3 O14649 5/20 0.64
▸ KCNK9 Q9NPC2 5/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17719152 0.91 SLC2A1 (0.76) SLC2A1KCNK3KCNK9
SCHEMBL16261531 0.90 SLC2A1 (1.00) SLC2A1KCNK3KCNK9
SCHEMBL17718829 0.89 SLC2A1 (0.88) SLC2A1KCNK3KCNK9
SCHEMBL17718807 0.88 SLC2A1 (0.94) SLC2A1KCNK3KCNK9
SCHEMBL17718936 0.87 SLC2A1 (0.86) SLC2A1KCNK3KCNK9
SCHEMBL17718896 0.87 SLC2A1 (0.81) SLC2A1KCNK3KCNK9
SCHEMBL17718942 0.85 SLC2A1 (1.00) SLC2A1KCNK3KCNK9
SCHEMBL17709590 0.85 SLC2A1 (0.80) SLC2A1KCNK3KCNK9
SCHEMBL17718911 0.83 SLC2A1 (0.78) SLC2A1KCNK3KCNK9
SCHEMBL17718837 0.83 SLC2A1 (0.84) SLC2A1KCNK3KCNK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160120863-A1 SLC2A TRANSPORTER INHIBITORS IOMET PHARMA LTD. (GB) 2016-05-05 — — US disclosed
US-20160120863-A1 SLC2A TRANSPORTER INHIBITORS IOMET PHARMA LTD. (GB) 2016-05-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160120863-A1 SLC2A TRANSPORTER INHIBITORS SLCO1A2, SLCO2B1, SLCO2A1 SLC2A1 6/4885KCNK3 2898/4885KCNK9 2405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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