Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 6/20 | 1.00 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.83 |
| ▸ | FES | P07332 | 2/20 | 0.81 |
| ▸ | FLT3 | P36888 | 2/20 | 0.81 |
| ▸ | IGF1R | P08069 | 4/20 | 0.77 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.77 |
| ▸ | GAK | O14976 | 2/20 | 0.77 |
| ▸ | INSR | P06213 | 2/20 | 0.77 |
| ▸ | INSRR | P14616 | 2/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.77 |
| ▸ | LTK | P29376 | 2/20 | 0.77 |
| ▸ | CLK1 | P49759 | 2/20 | 0.77 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.77 |
| ▸ | TNK1 | Q13470 | 2/20 | 0.77 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.77 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.65 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.62 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.61 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | STK25 | O00506 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29519543 | 0.92 | TTK (0.85) | TTKALKFESFLT3IGF1R | |
| SCHEMBL17731736 | 0.91 | TTK (1.00) | TTKALKFESFLT3IGF1R | |
| SCHEMBL3954048 | 0.90 | FES (1.00) | TTKALKFESFLT3IGF1R | |
| SCHEMBL14866359 | 0.89 | TTK (0.81) | TTKALKFESFLT3IGF1R | |
| SCHEMBL18018796 | 0.87 | TTK (0.80) | TTKALKFESFLT3IGF1R | |
| SCHEMBL29446147 | 0.87 | ALK (1.00) | TTKALKFESFLT3IGF1R | |
| SCHEMBL4051419 | 0.87 | ALK (1.00) | TTKALKFESFLT3IGF1R | |
| SCHEMBL29446184 | 0.87 | ALK (1.00) | TTKALKFESFLT3IGF1R | |
| SCHEMBL14866207 | 0.86 | ALK (0.84) | TTKALKFESFLT3IGF1R | |
| SCHEMBL17731758 | 0.86 | TTK (0.75) | TTKALKFESFLT3IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10611765-B2 | Pyrrolopyrimidine derivatives as Mps1/TTK kinase inhibitors | OHIO STATE INNOVATION FOUNDATION | 2020-04-07 | — | — | US | disclosed |
| US-10611765-B2 | Pyrrolopyrimidine derivatives as Mps1/TTK kinase inhibitors | OHIO STATE INNOVATION FOUNDATION | 2020-04-07 | — | — | US | disclosed |
| US-20190106422-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS MPS1/TTK KINASE INHIBITORS | OHIO STATE INNOVATION FOUNDATION | 2019-04-11 | — | — | US | disclosed |
| US-20190106422-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS MPS1/TTK KINASE INHIBITORS | OHIO STATE INNOVATION FOUNDATION | 2019-04-11 | — | — | US | disclosed |
| WO-2016073771-A2 | PYRROLOPYRIMIDINE DERIVATIVES AS MPS1/TTK KINASE INHIBITORS | OHIO STATE INNOVATION FOUNDATION (US) | 2016-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190106422-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS MPS1/TTK KINASE INHIBITORS | TTBK1, TTK, TTBK2 | TTK 2/4885ALK 1264/4885FES 95/4885 |
| US-10611765-B2 | Pyrrolopyrimidine derivatives as Mps1/TTK kinase inhibitors | TTBK1, TTK, TTBK2 | TTK 2/4885ALK 1264/4885FES 95/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.