Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.92 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.78 |
| ▸ | EED | O75530 | 1/20 | 0.78 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.78 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.78 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.78 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.78 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.78 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.78 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.78 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13277476 | 0.96 | EZH2 (1.00) | EZH2NR1I2EEDABCB11PDE4D | |
| SCHEMBL21162199 | 0.94 | EZH2 (0.87) | EZH2NR1I2EEDABCB11PDE4D | |
| SCHEMBL13276864 | 0.92 | EZH2 (1.00) | EZH2NR1I2EEDABCB11PDE4D | |
| SCHEMBL13281293 | 0.91 | EZH2 (1.00) | EZH2NR1I2EEDABCB11PDE4D | |
| SCHEMBL13277143 | 0.90 | EZH2 (0.89) | EZH2NR1I2EEDABCB11PDE4D | |
| SCHEMBL13276541 | 0.90 | EZH2 (1.00) | EZH2NR1I2EEDABCB11PDE4D | |
| SCHEMBL31087436 | 0.90 | EZH2 (1.00) | EZH2NR1I2EEDABCB11PDE4D | |
| SCHEMBL21915997 | 0.89 | EZH2 (0.97) | EZH2NR1I2EEDABCB11PDE4D | |
| SCHEMBL13446365 | 0.88 | EZH2 (0.92) | EZH2NR1I2EEDABCB11PDE4D | |
| SCHEMBL13276853 | 0.88 | EZH2 (1.00) | EZH2NR1I2EEDABCB11PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9334527-B2 | Inhibitors of human EZH2, and methods of use thereof | Epizyme, Inc. (US) | 2016-05-10 | — | — | US | disclosed |