Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 18/20 | 0.89 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30878122 | 0.94 | EZH2 (1.00) | EZH2HDAC1HDAC6 | |
| SCHEMBL13280847 | 0.94 | EZH2 (1.00) | EZH2HDAC1HDAC6 | |
| SCHEMBL13276839 | 0.94 | EZH2 (1.00) | EZH2HDAC1HDAC6 | |
| SCHEMBL30688033 | 0.94 | EZH2 (1.00) | EZH2HDAC1HDAC6 | |
| SCHEMBL13276782 | 0.94 | EZH2 (0.88) | EZH2HDAC1HDAC6 | |
| SCHEMBL13277416 | 0.94 | EZH2 (1.00) | EZH2HDAC1HDAC6 | |
| SCHEMBL13276863 | 0.93 | EZH2 (0.86) | EZH2HDAC1HDAC6 | |
| SCHEMBL28530613 | 0.91 | EZH2 (0.83) | EZH2HDAC1HDAC6 | |
| SCHEMBL13277257 | 0.91 | EZH2 (1.00) | EZH2HDAC1HDAC6 | |
| SCHEMBL30688044 | 0.91 | EZH2 (1.00) | EZH2HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9334527-B2 | Inhibitors of human EZH2, and methods of use thereof | Epizyme, Inc. (US) | 2016-05-10 | — | — | US | disclosed |