Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 17/20 | 0.59 |
| ▸ | EED | O75530 | 3/20 | 0.53 |
| ▸ | SUZ12 | Q15022 | 3/20 | 0.53 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.53 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.53 |
| ▸ | EZH1 | Q92800 | 4/20 | 0.51 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.51 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.51 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23863695 | 0.95 | EZH2 (0.53) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL23863648 | 0.85 | EZH2 (0.44) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL17734365 | 0.83 | EZH2 (0.63) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL14816657 | 0.78 | EZH2 (0.60) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL17734373 | 0.78 | EZH2 (0.78) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL23863694 | 0.78 | EZH2 (0.57) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL19503400 | 0.78 | EZH2 (0.80) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL24227159 | 0.77 | EZH2 (0.62) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL14816665 | 0.77 | EZH2 (0.58) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL17734413 | 0.76 | EZH2 (0.71) | EZH2EEDSUZ12RBBP4AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236082-B2 | EZH2 inhibitors and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-01 | — | — | US | disclosed |
| US-20190000860-A1 | USE OF COMPOSITIONS MODULATING CHROMATIN STRUCTURE FOR GRAFT VERSUS HOST DISEASE (GVHD) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-01-03 | — | — | US | disclosed |
| WO-2016073956-A1 | EZH2 INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-05-12 | — | — | WO | disclosed |
| WO-2016073903-A1 | USE OF COMPOSITIONS MODULATING CHROMATIN STRUCTURE FOR GRAFT VERSUS HOST DISEASE (GVHD) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190000860-A1 | USE OF COMPOSITIONS MODULATING CHROMATIN STRUCTURE FOR GRAFT VERSUS HOST DISEASE (GVHD) | BCL6, BCL6B, EZH2 | EZH2 3/4885EED 58/4885SUZ12 40/4885 |
| US-11236082-B2 | EZH2 inhibitors and uses thereof | EZH2, EZH1, BMI1 | EZH2 1/4885EED 5/4885SUZ12 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.