Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 9/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | VHL | P40337 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257723 | 0.92 | NR1H3 (0.35) | NR1H3ALDH1A1KDM4EMAOBS1PR3 | |
| SCHEMBL2238632 | 0.92 | NR1H3 (0.35) | NR1H3ALDH1A1KDM4EMAOBS1PR3 | |
| SCHEMBL177103 | 0.91 | NR1H3 (0.35) | NR1H3ALDH1A1KDM4EMAOBS1PR3 | |
| SCHEMBL176796 | 0.91 | NR1H3 (0.35) | NR1H3ALDH1A1KDM4EMAOBS1PR3 | |
| SCHEMBL176959 | 0.90 | NR1H3 (0.37) | NR1H3ALDH1A1MAOBS1PR3HCRTR2 | |
| SCHEMBL11897468 | 0.85 | MCL1 (0.37) | NR1H3NR1H2ATM | |
| SCHEMBL11897466 | 0.85 | MCL1 (0.37) | NR1H3NR1H2ATM | |
| SCHEMBL2240516 | 0.84 | NR1H3 (0.33) | NR1H3ALDH1A1KDM4EMAOBS1PR3 | |
| SCHEMBL176902 | 0.84 | NR1H3 (0.33) | NR1H3ALDH1A1KDM4EMAOBS1PR3 | |
| SCHEMBL2303787 | 0.84 | MCL1 (0.34) | NR1H3ALDH1A1KDM4EMAOBS1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2345644-A1 | INDAZOLE COMPOUND | Asahi Kasei Pharma Corporation (JP) | 2011-07-20 | — | — | EP | disclosed |