Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 8/20 | 0.75 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.59 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.59 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.59 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.57 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.56 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.55 |
| ▸ | RRM1 | P23921 | 1/20 | 0.53 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.50 |
| ▸ | CASP2 | P42575 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11778026 | 0.98 | EPHX1 (0.79) | EPHX1GNAI3GNAO1GNAI1PAOX | |
| SCHEMBL17740104 | 0.98 | EPHX1 (0.79) | EPHX1GNAI3GNAO1GNAI1PAOX | |
| SCHEMBL11780869 | 0.98 | EPHX1 (0.79) | EPHX1GNAI3GNAO1GNAI1PAOX | |
| SCHEMBL11780971 | 0.98 | EPHX1 (0.79) | EPHX1GNAI3GNAO1GNAI1PAOX | |
| SCHEMBL21538794 | 0.98 | EPHX1 (0.79) | EPHX1GNAI3GNAO1GNAI1PAOX | |
| SCHEMBL11779199 | 0.98 | EPHX1 (0.79) | EPHX1GNAI3GNAO1GNAI1PAOX | |
| SCHEMBL11778781 | 0.94 | EPHX1 (0.79) | EPHX1GNAI3GNAO1GNAI1PAOX | |
| SCHEMBL11779920 | 0.94 | EPHX1 (0.79) | EPHX1GNAI3GNAO1GNAI1PAOX | |
| SCHEMBL11783179 | 0.94 | EPHX1 (0.76) | EPHX1GNAI3GNAO1GNAI1PAOX | |
| SCHEMBL11778653 | 0.94 | EPHX1 (0.76) | EPHX1GNAI3GNAO1GNAI1PAOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016071856-A1 | AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE | NOVARTIS AG (CH) | 2016-05-12 | — | — | WO | disclosed |