Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 20/20 | 0.82 |
| ▸ | FLT1 | P17948 | 1/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.54 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.54 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.54 |
| ▸ | FLT4 | P35916 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | FRS2 | Q8WU20 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16342392 | 0.90 | FGFR1 (1.00) | FGFR1FLT1FGFR2FGFR4FGFR3 | |
| SCHEMBL16342680 | 0.90 | FGFR1 (0.67) | FGFR1FLT1FGFR2FGFR4FGFR3 | |
| SCHEMBL17745064 | 0.86 | FGFR1 (0.72) | FGFR1FLT1FGFR2FGFR4FGFR3 | |
| SCHEMBL16342707 | 0.85 | FGFR1 (0.81) | FGFR1FLT1FGFR2FGFR4FGFR3 | |
| SCHEMBL20486008 | 0.83 | FGFR1 (0.65) | FGFR1FLT1FGFR2FGFR4FGFR3 | |
| SCHEMBL14862995 | 0.83 | FGFR1 (0.84) | FGFR1FLT1FGFR2FGFR4FGFR3 | |
| SCHEMBL14863208 | 0.81 | FGFR1 (1.00) | FGFR1FLT1FGFR2FGFR4FGFR3 | |
| SCHEMBL17745059 | 0.81 | FGFR1 (0.67) | FGFR1FLT1FGFR2FGFR4FGFR3 | |
| SCHEMBL14863303 | 0.80 | FGFR1 (0.71) | FGFR1FLT1FGFR2FGFR4FGFR3 | |
| SCHEMBL14863079 | 0.79 | FGFR1 (1.00) | FGFR1FLT1FGFR2FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447091-B2 | Protein kinase inhibitors | ORION CORPORATION (FI) | 2016-09-20 | — | — | US | disclosed |
| EP-2766354-B1 | PROTEIN KINASE INHIBITORS | ORION CORP (FI) | 2016-05-18 | — | — | EP | disclosed |