Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 0.60 |
| ▸ | ACE | P12821 | 2/20 | 0.60 |
| ▸ | MMEL1 | Q495T6 | 2/20 | 0.59 |
| ▸ | MMP2 | P08253 | 9/20 | 0.57 |
| ▸ | MMP1 | P03956 | 4/20 | 0.57 |
| ▸ | MMP3 | P08254 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12317230 | 1.00 | MME (0.60) | MMEACEMMEL1MMP2MMP1 | |
| SCHEMBL18672518 | 1.00 | MME (0.60) | MMEACEMMEL1MMP2MMP1 | |
| SCHEMBL10197932 | 1.00 | MME (0.60) | MMEACEMMEL1MMP2MMP1 | |
| SCHEMBL18672812 | 1.00 | MME (0.60) | MMEACEMMEL1MMP2MMP1 | |
| SCHEMBL12317228 | 0.86 | MME (0.64) | MMEACEMMEL1 | |
| SCHEMBL18672582 | 0.86 | MME (0.64) | MMEACEMMEL1 | |
| SCHEMBL12317280 | 0.84 | MME (0.71) | MMEACEMMEL1 | |
| SCHEMBL18672615 | 0.84 | MME (0.71) | MMEACEMMEL1 | |
| SCHEMBL2877500 | 0.79 | MME (0.64) | MMEACEMMEL1 | |
| SCHEMBL2877505 | 0.79 | MME (0.64) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3048100-A1 | SUBSTITUTED AMINOBUTYRIC DERIVATIVES AS NEPRILYSIN INHIBITORS | Novartis AG (CH) | 2016-07-27 | — | — | EP | disclosed |
| EP-2640375-B1 | METHOD OF TREATING CONTRAST-INDUCED NEPHROPATHY | NOVARTIS AG (CH) | 2016-05-18 | — | — | EP | disclosed |