SCHEMBL177452

SCHEMBL177452

CC(C)N(Cc1ccc(-c2ccc(CCNCC(=O)O)cc2)cc1)c1ccc(F)cc1

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 2/20 0.55
MCHR1 Q99705 2/20 0.46
KMT2A Q03164 5/20 0.42
MEN1 O00255 3/20 0.42
KDM4E B2RXH2 2/20 0.41
ALDH1A1 P00352 2/20 0.41
RAB9A P51151 1/20 0.41
APAF1 O14727 1/20 0.40
MAPT P10636 1/20 0.40
HTT P42858 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
LMNA P02545 1/20 0.40
POLB P06746 1/20 0.40
KCNH2 Q12809 1/20 0.39
LTB4R2 Q9NPC1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17503651 0.79 S1PR1 (0.59) S1PR1MCHR1KMT2AMEN1TDP1
SCHEMBL177322 0.79 S1PR1 (0.59) S1PR1MCHR1KMT2AMEN1ALDH1A1
SCHEMBL16034258 0.78 KDM4E (0.61) KMT2AKDM4EALDH1A1RAB9AHTT
SCHEMBL177116 0.75 S1PR1 (0.55) S1PR1MCHR1KMT2AALDH1A1LTB4R2
SCHEMBL177596 0.74 S1PR1 (0.53) S1PR1MCHR1KMT2AMEN1ALDH1A1
SCHEMBL25360940 0.71 FFAR1 (0.65) HTTLMNA
SCHEMBL177204 0.71 S1PR1 (1.00) S1PR1HTT
SCHEMBL177055 0.71 S1PR1 (0.38) S1PR1MCHR1LMNAKCNH2
SCHEMBL566497 0.70 S1PR1 (0.49) S1PR1MCHR1ALDH1A1SMN1; SMN2LTB4R2
SCHEMBL566496 0.70 S1PR1 (0.49) S1PR1MCHR1ALDH1A1SMN1; SMN2LTB4R2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2344484-B1 S1P RECEPTORS MODULATORS AND USE THEREOF AKAAL PHARMA PTY LTD (AU) 2016-06-08 EP disclosed
EP-2344484-A1 S1P RECEPTORS MODULATORS AND THEIR USE THEREOF Akaal Pharma Pty Ltd (AU) 2011-07-20 EP disclosed
WO-2010043000-A1 S1P RECEPTORS MODULATORS AND THEIR USE THEREOF AKAAL PHARMA PTY LTD (AU) 2010-04-22 WO disclosed