Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 4/20 | 0.71 |
| ▸ | PIM1 | P11309 | 2/20 | 0.71 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.71 |
| ▸ | CDK2 | P24941 | 16/20 | 0.65 |
| ▸ | CCNA2 | P20248 | 12/20 | 0.65 |
| ▸ | AURKA | O14965 | 11/20 | 0.65 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.65 |
| ▸ | CDK4 | P11802 | 5/20 | 0.64 |
| ▸ | CCND3 | P30281 | 5/20 | 0.64 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.64 |
| ▸ | PLK1 | P53350 | 3/20 | 0.55 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.55 |
| ▸ | PLK2 | Q9NYY3 | 3/20 | 0.55 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.53 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12698391 | 0.90 | TTK (0.74) | TTKPIM1PIM2CDK2CCNA2 | |
| SCHEMBL17745983 | 0.88 | CDK2 (0.71) | TTKPIM1PIM2CDK2CCNA2 | |
| Trifluoroacetic Acid SCHEMBL15377699 | 0.87 | TTK (0.68) | TTKPIM1PIM2CDK2CCNA2 | |
| SCHEMBL15378100 | 0.86 | CDK2 (0.65) | TTKCDK2CCNA2AURKACCNA1 | |
| SCHEMBL15377616 | 0.84 | CDK2 (0.75) | TTKPIM1PIM2CDK2CCNA2 | |
| SCHEMBL12698351 | 0.84 | TTK (1.00) | TTKPIM1PIM2CDK2CCNA2 | |
| SCHEMBL4171285 | 0.84 | CDK2 (0.83) | TTKPIM1PIM2CDK2CCNA2 | |
| Trifluoroacetic Acid SCHEMBL15377924 | 0.81 | TTK (0.90) | TTKPIM1PIM2CDK2CCNA2 | |
| SCHEMBL15377856 | 0.81 | CCNA2 (0.89) | TTKPIM1PIM2CDK2CCNA2 | |
| Trifluoroacetic Acid SCHEMBL15377887 | 0.81 | CDK2 (0.70) | TTKPIM1PIM2CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668188-B1 | TRICYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2016-05-18 | — | — | EP | claimed |