Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 7/20 | 0.86 |
| ▸ | PIM1 | P11309 | 1/20 | 0.86 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.86 |
| ▸ | AURKA | O14965 | 1/20 | 0.66 |
| ▸ | PLK1 | P53350 | 1/20 | 0.66 |
| ▸ | IGF1R | P08069 | 13/20 | 0.61 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.59 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.58 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.58 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.58 |
| ▸ | MELK | Q14680 | 1/20 | 0.58 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.58 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12698326 | 0.93 | TTK (0.81) | TTKPIM1PIM2AURKAPLK1 | |
| SCHEMBL12698376 | 0.93 | TTK (1.00) | TTKPIM1PIM2AURKAPLK1 | |
| Hydrochloric Acid SCHEMBL15377265 | 0.92 | TTK (0.99) | TTKPIM1PIM2AURKAPLK1 | |
| SCHEMBL17746009 | 0.92 | TTK (0.74) | TTKPIM1PIM2AURKAPLK1 | |
| SCHEMBL15377866 | 0.89 | TTK (0.82) | TTKPIM1PIM2AURKAPLK1 | |
| SCHEMBL17746010 | 0.87 | TTK (0.68) | TTKPIM1PIM2AURKAPLK1 | |
| SCHEMBL12499331 | 0.86 | TTK (0.79) | TTKPIM1PIM2AURKAPLK1 | |
| SCHEMBL12698406 | 0.84 | TTK (0.79) | TTKPIM1PIM2AURKAPLK1 | |
| SCHEMBL12698458 | 0.83 | TTK (1.00) | TTKPIM1PIM2AURKAPLK1 | |
| SCHEMBL1889494 | 0.82 | TTK (0.79) | TTKPIM1PIM2AURKAPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668188-B1 | TRICYCLIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2016-05-18 | — | — | EP | disclosed |