Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.78 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.78 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.78 |
| ▸ | RICTOR | Q6R327 | 3/20 | 0.78 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.78 |
| ▸ | MAPKAP1 | Q9BPZ7 | 3/20 | 0.78 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.78 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.78 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.67 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17748699 | 1.00 | MTOR (0.78) | MTORPIK3CAPIK3R1RICTORRPTOR | |
| SCHEMBL29880467 | 0.93 | MTOR (0.88) | MTORPIK3CAPIK3R1RICTORRPTOR | |
| SCHEMBL17748670 | 0.93 | MTOR (0.88) | MTORPIK3CAPIK3R1RICTORRPTOR | |
| SCHEMBL17748672 | 0.93 | MTOR (0.88) | MTORPIK3CAPIK3R1RICTORRPTOR | |
| SCHEMBL17748742 | 0.92 | MTOR (0.87) | MTORPIK3CAPIK3R1RICTORRPTOR | |
| SCHEMBL17748739 | 0.92 | MTOR (0.87) | MTORPIK3CAPIK3R1RICTORRPTOR | |
| SCHEMBL17748679 | 0.88 | MTOR (1.00) | MTORPIK3CAPIK3R1RICTORRPTOR | |
| SCHEMBL17748680 | 0.88 | MTOR (1.00) | MTORPIK3CAPIK3R1RICTORRPTOR | |
| SCHEMBL19629244 | 0.88 | MTOR (1.00) | MTORPIK3CAPIK3R1RICTORRPTOR | |
| SCHEMBL29549933 | 0.88 | MTOR (1.00) | MTORPIK3CAPIK3R1RICTORRPTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3218358-A1 | DIFLUOROMETHYL-AMINOPYRIDINES AND DIFLUOROMETHYL-AMINOPYRIMIDINES | PIQUR Therapeutics AG (CH) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016075130-A1 | DIFLUOROMETHYL-AMINOPYRIDINES AND DIFLUOROMETHYL-AMINOPYRIMIDINES | PIQUR THERAPEUTICS AG (CH) | 2016-05-19 | — | — | WO | disclosed |