SCHEMBL17748809

SCHEMBL17748809

CCCCCC(C#N)Cn1cc(-c2ncnc3[nH]ccc23)cn1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 20/20 0.66
JAK1 P23458 13/20 0.66
HDAC6 Q9UBN7 9/20 0.51
JAK3 P52333 11/20 0.50
HDAC1 Q13547 6/20 0.50
TYK2 P29597 5/20 0.50
HDAC3 O15379 2/20 0.49
HDAC2 Q92769 2/20 0.49
HDAC10 Q969S8 2/20 0.49
HDAC8 Q9BY41 2/20 0.49
HDAC5 Q9UQL6 2/20 0.49
NCOR2 Q9Y618 2/20 0.49
HDAC7 Q8WUI4 1/20 0.49
HDAC11 Q96DB2 1/20 0.49
RET P07949 3/20 0.48
ROCK1 Q13464 3/20 0.48
CIT O14578 2/20 0.48
GAK O14976 2/20 0.48
ROCK2 O75116 2/20 0.48
ULK1 O75385 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18602281 0.84 JAK2 (0.64) JAK2JAK1HDAC6JAK3HDAC1
SCHEMBL100975 0.83 JAK2 (0.55) JAK2JAK1HDAC6JAK3HDAC1
SCHEMBL20908684 0.81 JAK2 (0.69) JAK2JAK1HDAC6JAK3HDAC1
SCHEMBL859886 0.80 JAK2 (1.00) JAK2JAK1HDAC6JAK3HDAC1
SCHEMBL848835 0.80 JAK2 (1.00) JAK2JAK1HDAC6JAK3HDAC1
SCHEMBL860196 0.80 JAK2 (1.00) JAK2JAK1HDAC6JAK3HDAC1
SCHEMBL13695723 0.79 JAK2 (0.65) JAK2JAK1HDAC6JAK3HDAC1
SCHEMBL13774665 0.78 JAK2 (0.61) JAK2JAK1HDAC6JAK3HDAC1
SCHEMBL847365 0.78 JAK2 (0.80) JAK2JAK1HDAC6JAK3HDAC1
SCHEMBL29780369 0.78 JAK2 (0.80) JAK2JAK1HDAC6JAK3HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3218379-A1 SALTS OF (3R)-3-CYCLOPENTYL-3-[4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PYRAZOL-1-YL]PROPANENITRILE Zentiva K.S. (CZ) 2017-09-20 EP disclosed
WO-2016074650-A1 SALTS OF (3R)-3-CYCLOPENTYL-3-[4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PYRAZOL-1-YL]PROPANENITRILE ZENTIVA, K.S. (CZ) 2016-05-19 WO disclosed