Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 19/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | HRH1 | P35367 | 3/20 | 0.33 |
| ▸ | HRH2 | P25021 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1774997 | 1.00 | HRH4 (0.36) | HRH4HRH3KCNH2HRH1HRH2 | |
| SCHEMBL1775000 | 1.00 | HRH4 (0.36) | HRH4HRH3KCNH2HRH1HRH2 | |
| SCHEMBL1773721 | 0.87 | HRH4 (0.37) | HRH4HRH3KCNH2HRH1HRH2 | |
| SCHEMBL1773719 | 0.87 | HRH4 (0.37) | HRH4HRH3KCNH2HRH1HRH2 | |
| SCHEMBL1773718 | 0.87 | HRH4 (0.37) | HRH4HRH3KCNH2HRH1HRH2 | |
| SCHEMBL603790 | 0.86 | HRH4 (0.48) | HRH4HRH3KCNH2HRH1HRH2 | |
| Hydrochloric Acid SCHEMBL604796 | 0.85 | HRH4 (0.47) | HRH4HRH3KCNH2HRH1HRH2 | |
| SCHEMBL1774508 | 0.82 | HRH4 (0.34) | HRH4HRH3KCNH2HRH1HRH2 | |
| SCHEMBL1774121 | 0.80 | HRH4 (0.57) | HRH4HRH3KCNH2HRH1HRH2 | |
| SCHEMBL1775186 | 0.80 | HRH4 (0.57) | HRH4HRH3KCNH2HRH1HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943628-B2 | Pyrimidine derivatives | PFIZER LIMITED (GB) | 2011-05-17 | — | — | US | disclosed |