SCHEMBL17753752

SCHEMBL17753752

COc1c(C)cc(C(C)(C)c2cc(C)c(OC(=O)c3ccc(Oc4ccc(C(C)=O)cc4)cc3)c(C)c2)cc1C

nearest known ligand 0.47

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 6/20 0.47
▸ HPGD P15428 2/20 0.47
▸ RAB9A P51151 1/20 0.47
▸ ESRRA P11474 1/20 0.44
▸ KMT2A Q03164 7/20 0.40
▸ GAA P10253 1/20 0.38
▸ BRAF P15056 1/20 0.36
▸ PARP10 Q53GL7 1/20 0.36
▸ TDP1 Q9NUW8 2/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ CA1 P00915 1/20 0.36
▸ CA2 P00918 1/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ LMNA P02545 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ ELANE P08246 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16573870 0.94 KMT2A (0.39) MAPTHPGDRAB9AKMT2AGAA
SCHEMBL12346021 0.94 KMT2A (0.39) MAPTHPGDRAB9AKMT2AGAA
SCHEMBL12376966 0.88 MAPT (0.51) MAPTHPGDRAB9AESRRAKMT2A
SCHEMBL14007584 0.88 ESR1 (0.39) MAPTKMT2AGAATDP1L3MBTL1
SCHEMBL16938081 0.87 MAPT (0.44) MAPTHPGDRAB9AESRRAKMT2A
SCHEMBL13865060 0.85 ESR1 (0.39) MAPTHPGDKMT2AGAATDP1
SCHEMBL12376957 0.85 MAPT (0.47) MAPTHPGDRAB9AESRRAKMT2A
SCHEMBL13030397 0.85 CA1 (0.44) MAPTHPGDKMT2AGAATDP1
SCHEMBL17791454 0.84 MAPT (0.46) MAPTHPGDRAB9AESRRAKMT2A
SCHEMBL15493960 0.82 MAPT (0.50) MAPTKMT2APARP10TDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9684277-B2 Process cartridge and image-forming method CANON KABUSHIKI KAISHA (JP) 2017-06-20 — — US disclosed
US-20160139556-A1 PROCESS CARTRIDGE AND IMAGE-FORMING METHOD CANON KABUSHIKI KAISHA (JP) 2016-05-19 — — US disclosed
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