Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.51 |
| ▸ | TAF1 | P21675 | 3/20 | 0.50 |
| ▸ | CECR2 | Q9BXF3 | 3/20 | 0.50 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.50 |
| ▸ | BRD4 | O60885 | 6/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17753908 | 0.95 | TAF1 (0.52) | ACKR3TAF1CECR2BRD9BRD4 | |
| SCHEMBL17753667 | 0.91 | TAF1 (0.50) | TAF1CECR2BRD9BRD4KDM4E | |
| SCHEMBL17753688 | 0.90 | KDM4E (0.55) | TAF1CECR2BRD9BRD4JAK2 | |
| SCHEMBL17753963 | 0.86 | BRD9 (0.61) | TAF1CECR2BRD9BRD4 | |
| SCHEMBL17753897 | 0.85 | TAF1 (0.62) | TAF1CECR2BRD9BRD4JAK2 | |
| SCHEMBL17753896 | 0.84 | TAF1 (0.52) | TAF1CECR2BRD9BRD4KDM1A | |
| SCHEMBL17753668 | 0.84 | TAF1 (0.47) | TAF1CECR2BRD9BRD4JAK2 | |
| SCHEMBL17749004 | 0.83 | TAF1 (0.55) | TAF1CECR2BRD9BRD4JAK2 | |
| SCHEMBL17749030 | 0.82 | TAF1 (0.61) | TAF1CECR2BRD9BRD4KMT2A | |
| SCHEMBL17753682 | 0.82 | TAF1 (0.51) | TAF1CECR2BRD9BRD4METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10258603-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-04-16 | — | — | US | disclosed |
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
| WO-2016077375-A1 | BROMODOMAIN INHIBITORS AND USES THEREOF | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10258603-B2 | Therapeutic compounds and uses thereof | BRD4, BRDT, BRD3 | ACKR3 1580/4885TAF1 439/4885CECR2 184/4885 |
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | ACKR3 1580/4885TAF1 439/4885CECR2 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.