Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CECR2 | Q9BXF3 | 6/20 | 0.59 |
| ▸ | TAF1 | P21675 | 5/20 | 0.59 |
| ▸ | BRD9 | Q9H8M2 | 5/20 | 0.59 |
| ▸ | BRD4 | O60885 | 13/20 | 0.50 |
| ▸ | ATAD2 | Q6PL18 | 2/20 | 0.46 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17749030 | 0.90 | TAF1 (0.61) | CECR2TAF1BRD9BRD4EZH2 | |
| SCHEMBL17754070 | 0.89 | TAF1 (0.60) | CECR2TAF1BRD9BRD4EZH2 | |
| SCHEMBL17753694 | 0.89 | TAF1 (0.60) | CECR2TAF1BRD9BRD4EZH2 | |
| SCHEMBL17753893 | 0.88 | TAF1 (0.71) | CECR2TAF1BRD9BRD4ATAD2 | |
| SCHEMBL17753695 | 0.87 | TAF1 (0.58) | CECR2TAF1BRD9BRD4 | |
| SCHEMBL17753713 | 0.86 | TAF1 (0.58) | CECR2TAF1BRD9BRD4EZH2 | |
| SCHEMBL17753963 | 0.85 | BRD9 (0.61) | CECR2TAF1BRD9BRD4ATAD2 | |
| SCHEMBL17753692 | 0.85 | TAF1 (0.56) | CECR2TAF1BRD9BRD4 | |
| SCHEMBL17753701 | 0.83 | TAF1 (0.54) | CECR2TAF1BRD9BRD4EZH2 | |
| SCHEMBL17754167 | 0.83 | TAF1 (0.52) | CECR2TAF1BRD9BRD4ATAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016077375-A1 | BROMODOMAIN INHIBITORS AND USES THEREOF | GENENTECH, INC. (US) | 2016-05-19 | — | — | WO | disclosed |