Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | MPI | P34949 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29408147 | 0.97 | GAA (0.54) | GAAMEN1KMT2AMAPTKDM4E | |
| SCHEMBL123812 | 0.97 | GAA (0.54) | GAAMEN1KMT2AMAPTKDM4E | |
| SCHEMBL29144954 | 0.97 | GAA (0.54) | GAAMEN1KMT2AMAPTKDM4E | |
| SCHEMBL17758260 | 0.93 | GAA (0.52) | GAAMEN1KMT2AMAPTKDM4E | |
| Ammonia Solution, Strong SCHEMBL28409962 | 0.93 | GAA (0.52) | GAAMEN1KMT2AMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL7829799 | 0.93 | GAA (0.52) | GAAMEN1KMT2AMAPTKDM4E | |
| SCHEMBL8200265 | 0.88 | MEN1 (0.48) | GAAMEN1KMT2AMAPTKDM4E | |
| SCHEMBL13495065 | 0.88 | MEN1 (0.48) | GAAMEN1KMT2AMAPTKDM4E | |
| Pyrazine SCHEMBL26933885 | 0.85 | GAA (0.46) | GAAMEN1KMT2AMAPTKDM4E | |
| SCHEMBL4495411 | 0.84 | GAA (0.44) | GAAMEN1KMT2AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9346798-B2 | Dihydrobenzoxazine and tetrahydroquinoxaline sodium channel inhibitors | AMGEN INC. (US) | 2016-05-24 | — | — | US | disclosed |