Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591958 | 0.86 | TAAR1 (0.40) | TAAR1LMNAMMP8BACE1L3MBTL1 | |
| SCHEMBL2591960 | 0.86 | TAAR1 (0.40) | TAAR1LMNAMMP8BACE1L3MBTL1 | |
| SCHEMBL2591955 | 0.86 | TAAR1 (0.40) | TAAR1LMNAMMP8BACE1L3MBTL1 | |
| SCHEMBL2592172 | 0.84 | TAAR1 (0.37) | TAAR1LMNAMMP8BACE1L3MBTL1 | |
| SCHEMBL2592179 | 0.84 | TAAR1 (0.37) | TAAR1LMNAMMP8BACE1L3MBTL1 | |
| SCHEMBL2592177 | 0.84 | TAAR1 (0.37) | TAAR1LMNAMMP8BACE1L3MBTL1 | |
| SCHEMBL14703685 | 0.84 | TAAR1 (0.37) | TAAR1LMNAMMP8BACE1L3MBTL1 | |
| SCHEMBL14165827 | 0.83 | BACE1 (0.40) | TAAR1LMNAMMP8BACE1L3MBTL1 | |
| SCHEMBL14165829 | 0.83 | BACE1 (0.40) | TAAR1LMNAMMP8BACE1L3MBTL1 | |
| SCHEMBL14165828 | 0.83 | BACE1 (0.40) | TAAR1LMNAMMP8BACE1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016075064-A1 | 2-AMINO-5,5-DIFLUORO-6-(FLUOROMETHYL)-6-PHENYL-3,4,5,6-TETRAHYDROPYRIDINES AS BACE1 INHIBITORS | H. LUNDBECK A/S (DK) | 2016-05-19 | — | — | WO | disclosed |