SCHEMBL17763045

SCHEMBL17763045

Cn1nc(C(C)(C)NC(=O)[C@@H]2CNCCO2)c2cccc(C(F)(F)F)c21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
SSTR4 P31391 20/20 1.00
SSTR1 P30872 2/20 0.70
SSTR2 P30874 2/20 0.70
SSTR3 P32745 2/20 0.70
SSTR5 P35346 2/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17763108 0.89 SSTR4 (1.00) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL17763052 0.88 SSTR4 (1.00) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL17763040 0.87 SSTR4 (1.00) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL17763115 0.83 SSTR4 (1.00) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL16252716 0.82 SSTR4 (1.00) SSTR4SSTR1
SCHEMBL19724588 0.82 SSTR4 (1.00) SSTR4SSTR1
SCHEMBL19724546 0.82 SSTR4 (1.00) SSTR4SSTR1
SCHEMBL17763143 0.79 SSTR4 (0.66) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL17763071 0.78 SSTR4 (1.00) SSTR4SSTR1SSTR2SSTR3SSTR5
SCHEMBL17763070 0.78 SSTR4 (1.00) SSTR4SSTR1SSTR2SSTR3SSTR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3218372-B1 MORPHOLINE AND 1,4-OXAZEPANE AMIDES AS SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS BOEHRINGER INGELHEIM INT (DE) 2020-05-20 EP disclosed
US-10577336-B2 Morpholine and 1,4-oxazepane amides as somatostatin receptor subtype 4 (SSTR4) agonists BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2020-03-03 US disclosed
US-20170320838-A1 MORPHOLINE AND 1,4-OXAZEPANE AMIDES AS SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2017-11-09 US disclosed
US-20170320838-A1 MORPHOLINE AND 1,4-OXAZEPANE AMIDES AS SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2017-11-09 US disclosed
WO-2016075240-A1 MORPHOLINE AND 1,4-OXAZEPANE AMIDES AS SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2016-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170320838-A1 MORPHOLINE AND 1,4-OXAZEPANE AMIDES AS SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS SSTR4, SSTR1, SSTR3 SSTR4 1/4885SSTR1 2/4885SSTR2 5/4885
US-10577336-B2 Morpholine and 1,4-oxazepane amides as somatostatin receptor subtype 4 (SSTR4) agonists SSTR4, SSTR1, SSTR3 SSTR4 1/4885SSTR1 2/4885SSTR2 5/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.