Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.68 |
| ▸ | IGF1R | P08069 | 2/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 12/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1777235 | 0.93 | SYK (0.59) | SYKIGF1RRIPK1CCNE1CDK2 | |
| SCHEMBL1776988 | 0.90 | SYK (0.74) | SYKIGF1RRIPK1JAK2LCK | |
| SCHEMBL1778650 | 0.86 | SYK (0.70) | SYKIGF1RRIPK1JAK2LCK | |
| SCHEMBL1777627 | 0.85 | SYK (0.75) | SYKIGF1RRIPK1JAK2LCK | |
| SCHEMBL13157584 | 0.85 | SYK (0.72) | SYKIGF1RRIPK1JAK2LCK | |
| SCHEMBL1777487 | 0.84 | SYK (0.63) | SYKIGF1RRIPK1 | |
| SCHEMBL1777522 | 0.83 | SYK (0.70) | SYKIGF1RRIPK1JAK2LCK | |
| SCHEMBL1778035 | 0.83 | SYK (0.64) | SYKIGF1RRIPK1JAK2LCK | |
| SCHEMBL1778784 | 0.83 | SYK (0.71) | SYKIGF1RRIPK1JAK2LCK | |
| SCHEMBL1779125 | 0.83 | SYK (0.71) | SYKIGF1RRIPK1JAK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| EP-2233486-A1 | Azaindoles | Aventis Pharma Limited (GB) | 2010-09-29 | — | — | EP | disclosed |