Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1781013 | 0.99 | MAPT (0.43) | MAPTSMN1; SMN2HTTMAPK1ALDH1A1 | |
| SCHEMBL4587250 | 0.81 | MAPT (0.52) | MAPTSMN1; SMN2HTTMAPK1ALDH1A1 | |
| SCHEMBL1779615 | 0.81 | MAPT (0.48) | MAPTSMN1; SMN2HTTMAPK1ALDH1A1 | |
| SCHEMBL1779616 | 0.81 | MAPT (0.48) | MAPTSMN1; SMN2HTTMAPK1ALDH1A1 | |
| SCHEMBL1778567 | 0.79 | MAPT (0.48) | MAPTSMN1; SMN2HTTMAPK1ALDH1A1 | |
| SCHEMBL1778569 | 0.79 | MAPT (0.48) | MAPTSMN1; SMN2HTTMAPK1ALDH1A1 | |
| SCHEMBL4589136 | 0.77 | MAPT (0.44) | MAPTSMN1; SMN2HTTMAPK1ALDH1A1 | |
| SCHEMBL4587969 | 0.76 | MAPT (0.45) | MAPTSMN1; SMN2HTTMAPK1ALDH1A1 | |
| SCHEMBL1778139 | 0.76 | MAPT (0.46) | MAPTSMN1; SMN2HTTMAPK1ALDH1A1 | |
| SCHEMBL4588286 | 0.74 | MAPT (0.49) | MAPTSMN1; SMN2HTTMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943768-B2 | Piperazine compounds useful as antagonists of C-C chemokines (Ccr2b and CcrS) for the treatment of inflammatory diseases | ASTRAZENECA AB (SE) | 2011-05-17 | — | — | US | disclosed |