Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 6/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 7/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19714195 | 1.00 | CNR2 (0.35) | CNR2ARAXLCNR1FAAH | |
| SCHEMBL19714197 | 1.00 | CNR2 (0.35) | CNR2ARAXLCNR1FAAH | |
| SCHEMBL17770427 | 1.00 | CNR2 (0.35) | CNR2ARAXLCNR1FAAH | |
| SCHEMBL19714570 | 0.89 | TRPV1 (0.39) | CNR2AXLCNR1 | |
| SCHEMBL19714404 | 0.89 | TRPV1 (0.39) | CNR2AXLCNR1 | |
| SCHEMBL17777088 | 0.89 | TRPV1 (0.39) | CNR2AXLCNR1 | |
| SCHEMBL19713781 | 0.89 | CNR2 (0.38) | CNR2AXLCNR1FAAH | |
| SCHEMBL19713778 | 0.89 | CNR2 (0.38) | CNR2AXLCNR1FAAH | |
| SCHEMBL19714495 | 0.87 | ACKR3 (0.33) | CNR2AXLCNR1 | |
| SCHEMBL17776454 | 0.87 | ACKR3 (0.33) | CNR2AXLCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221317-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016079710-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |