Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.66 |
| ▸ | JAK3 | P52333 | 8/20 | 0.66 |
| ▸ | JAK1 | P23458 | 6/20 | 0.66 |
| ▸ | EGFR | P00533 | 9/20 | 0.50 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 2/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17770580 | 0.87 | EGFR (0.66) | JAK2JAK3JAK1EGFRMAP2K7 | |
| SCHEMBL19550929 | 0.79 | JAK2 (1.00) | JAK2JAK3JAK1EGFRMAP2K7 | |
| SCHEMBL19476922 | 0.79 | JAK2 (0.62) | JAK2JAK3JAK1EGFRBTK | |
| SCHEMBL19476921 | 0.79 | JAK2 (0.62) | JAK2JAK3JAK1EGFRBTK | |
| SCHEMBL18131947 | 0.78 | BTK (0.71) | JAK3EGFRITKBTK | |
| SCHEMBL18476813 | 0.78 | BTK (0.71) | JAK3EGFRITKBTK | |
| SCHEMBL30079960 | 0.78 | JAK2 (0.61) | JAK2JAK3JAK1EGFRBTK | |
| SCHEMBL19463433 | 0.78 | JAK2 (0.61) | JAK2JAK3JAK1EGFRBTK | |
| SCHEMBL17770583 | 0.76 | JAK2 (0.77) | JAK2JAK3JAK1EGFRMAP2K7 | |
| SCHEMBL18642030 | 0.76 | JAK2 (0.65) | JAK2JAK3JAK1EGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3221320-A1 | A PROCESS FOR THE PREPARATION OF IBRUTINIB | Sun Pharmaceutical Industries Ltd (IN) | 2017-09-27 | — | — | EP | disclosed |
| WO-2016079693-A1 | A PROCESS FOR THE PREPARATION OF IBRUTINIB | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2016-05-26 | — | — | WO | disclosed |