Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 19/20 | 0.76 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1434490 | 0.86 | PDE4D (1.00) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL1434700 | 0.84 | PDE4D (0.81) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL885393 | 0.84 | PDE4D (0.81) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL885298 | 0.82 | PDE4D (0.81) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL885255 | 0.81 | PDE4D (1.00) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL17772015 | 0.80 | PDE4D (0.78) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL1434816 | 0.80 | PDE4D (0.60) | PDE4DPDE4B | |
| SCHEMBL1434091 | 0.79 | PDE4D (0.80) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL885350 | 0.79 | PDE4D (0.83) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL1434386 | 0.79 | PDE4D (0.80) | PDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3070091-A1 | BENZODIOXOLE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | LEO PHARMA A/S (DK) | 2016-09-21 | — | — | EP | disclosed |
| EP-2585469-B1 | BENZODIOXOLE OR BENZODIOXEPINE HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-05-25 | — | — | EP | disclosed |