Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17772015 | 0.84 | PDE4D (0.78) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1434080 | 0.79 | PDE4D (0.60) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1434406 | 0.77 | PDE4D (0.65) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1435157 | 0.75 | PDE4D (0.64) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1434224 | 0.75 | PDE4D (0.75) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1697738 | 0.74 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| SCHEMBL14936339 | 0.73 | PDE4A (1.00) | PDE4APDE4DPDE4BPDE3BPDE3A | |
| SCHEMBL1434359 | 0.73 | PDE4D (0.74) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL1434242 | 0.72 | PDE4D (1.00) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL5794189 | 0.72 | PDE4D (0.50) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585469-B1 | BENZODIOXOLE OR BENZODIOXEPINE HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2016-05-25 | — | — | EP | disclosed |