Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 3/20 | 0.58 |
| ▸ | LCK | P06239 | 3/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.58 |
| ▸ | GSK3A | P49840 | 2/20 | 0.58 |
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
| ▸ | CDK7 | P50613 | 2/20 | 0.58 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | BTK | Q06187 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | MET | P08581 | 3/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1776936 | 0.93 | IGF1R (0.58) | IGF1RLCKAURKBGSK3AGSK3B | |
| SCHEMBL12606274 | 0.91 | IGF1R (0.56) | IGF1RLCKAURKBGSK3AGSK3B | |
| SCHEMBL1777688 | 0.89 | IGF1R (0.57) | IGF1RLCKAURKBGSK3AGSK3B | |
| SCHEMBL1778662 | 0.88 | IGF1R (0.56) | IGF1RLCKAURKBGSK3AGSK3B | |
| SCHEMBL12606329 | 0.87 | LCK (0.55) | IGF1RLCKAURKBGSK3AGSK3B | |
| SCHEMBL1777230 | 0.86 | IGF1R (0.66) | IGF1RLCKAURKBGSK3AGSK3B | |
| SCHEMBL12606258 | 0.86 | IGF1R (0.58) | IGF1RLCKAURKBGSK3AGSK3B | |
| SCHEMBL12606334 | 0.84 | LCK (0.56) | IGF1RLCKAURKBGSK3AGSK3B | |
| SCHEMBL1777922 | 0.84 | SYK (0.59) | IGF1RLCKAURKBGSK3AGSK3B | |
| SCHEMBL12606309 | 0.83 | IGF1R (0.62) | IGF1RLCKAURKBGSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| US-7943616-B2 | Protein kinase inhibitors; astham; psoriasis; antiinflammatory agents; inflammatory bowel disorders | AVENTIS PHARMACEUTICALS INC. (US) | 2011-05-17 | — | — | US | disclosed |
| EP-2233486-A1 | Azaindoles | Aventis Pharma Limited (GB) | 2010-09-29 | — | — | EP | disclosed |