Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19043665 | 0.70 | OPRL1 (0.35) | DPP8DPP9OPRL1DRD2DRD3 | |
| SCHEMBL1698223 | 0.70 | OPRL1 (0.40) | OPRL1DRD2DRD3KCNH2 | |
| SCHEMBL21555729 | 0.69 | ANPEP (0.40) | OPRL1KCNH2SLC18A3P2RX7 | |
| Hydrochloric Acid SCHEMBL17768575 | 0.68 | ANPEP (0.42) | OPRL1KCNH2SLC18A3P2RX7 | |
| SCHEMBL1698222 | 0.68 | CXCR4 (0.44) | KCNH2 | |
| SCHEMBL14267785 | 0.68 | SLC18A3 (0.40) | TSHRSLC18A3P2RX7 | |
| SCHEMBL14016085 | 0.68 | SLC18A3 (0.40) | TSHRSLC18A3P2RX7 | |
| SCHEMBL18959591 | 0.67 | DRD3 (0.39) | OPRL1DRD2DRD3KCNH2LMNA | |
| SCHEMBL19043677 | 0.67 | OPRL1 (0.40) | OPRL1DRD2DRD3KCNH2 | |
| SCHEMBL24993142 | 0.67 | CCNA2 (0.38) | DPP8DPP9OPRL1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016081290-A1 | AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES | MERCK SHARP & DOHME CORP. (US) | 2016-05-26 | — | — | WO | disclosed |