Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.32 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
| ▸ | CPT1A | P50416 | 1/20 | 0.31 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 2/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 3/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.30 |
| ▸ | KDR | P35968 | 2/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.30 |
| ▸ | SCN1A | P35498 | 1/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20550417 | 0.95 | CPT2 (0.36) | PRMT5WDR77CPT2CPT1ACPT1B | |
| SCHEMBL20550416 | 0.95 | CPT2 (0.36) | PRMT5WDR77CPT2CPT1ACPT1B | |
| SCHEMBL17769754 | 0.95 | CPT2 (0.36) | PRMT5WDR77CPT2CPT1ACPT1B | |
| SCHEMBL17769401 | 0.91 | CPT2 (0.37) | PRMT5WDR77CPT2CPT1ACPT1B | |
| SCHEMBL17769483 | 0.91 | CPT2 (0.37) | PRMT5WDR77CPT2CPT1ACPT1B | |
| SCHEMBL17769487 | 0.91 | CPT2 (0.37) | PRMT5WDR77CPT2CPT1ACPT1B | |
| SCHEMBL17778223 | 0.89 | TRPV1 (0.32) | ADRB3ADRB2ADRB1ROCK2 | |
| SCHEMBL20550364 | 0.86 | TRPV1 (0.35) | PRMT5WDR77CPT2CPT1ACPT1B | |
| SCHEMBL17769718 | 0.86 | TRPV1 (0.35) | PRMT5WDR77CPT2CPT1ACPT1B | |
| SCHEMBL17769667 | 0.86 | TRPV1 (0.35) | PRMT5WDR77CPT2CPT1ACPT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079712-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |