Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 10/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19689781 | 1.00 | IRAK4 (0.35) | IRAK4KCNH2EGFRKDM5APIK3C3 | |
| SCHEMBL19689744 | 0.90 | PIK3C3 (0.41) | IRAK4KCNH2PIK3C3MAPK1CSNK1D | |
| SCHEMBL17778665 | 0.90 | PIK3C3 (0.41) | IRAK4KCNH2PIK3C3MAPK1CSNK1D | |
| SCHEMBL17778744 | 0.90 | RAF1 (0.39) | IRAK4KCNH2PIK3C3 | |
| SCHEMBL19689861 | 0.89 | CCNE1 (0.36) | IRAK4KCNH2EGFRFGFR1FGFR2 | |
| SCHEMBL19706746 | 0.89 | RAF1 (0.35) | IRAK4KCNH2EGFRABL1DYRK1A | |
| SCHEMBL19689724 | 0.89 | RAF1 (0.35) | IRAK4KCNH2EGFRABL1DYRK1A | |
| SCHEMBL19689811 | 0.89 | DYRK1A (0.42) | IRAK4KCNH2PIK3C3ABL1MAPK1 | |
| SCHEMBL17778803 | 0.89 | DYRK1A (0.42) | IRAK4KCNH2PIK3C3ABL1MAPK1 | |
| SCHEMBL19689684 | 0.89 | IRAK4 (0.36) | IRAK4KCNH2EGFRKDM5APIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016079709-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2016-05-26 | — | — | WO | disclosed |