Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 8/20 | 0.39 |
| ▸ | TAF1 | P21675 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.38 |
| ▸ | VRK1 | Q99986 | 6/20 | 0.37 |
| ▸ | PLK1 | P53350 | 7/20 | 0.37 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.37 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.36 |
| ▸ | PLK2 | Q9NYY3 | 3/20 | 0.36 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.36 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.36 |
| ▸ | MARK3 | P27448 | 1/20 | 0.35 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17780337 | 0.99 | BRD4 (0.39) | BRD4TAF1PARP1MAPK7VRK1 | |
| SCHEMBL17780559 | 0.95 | VRK1 (0.37) | BRD4TAF1PARP1MAPK7VRK1 | |
| SCHEMBL17780591 | 0.95 | VRK1 (0.37) | BRD4TAF1PARP1MAPK7VRK1 | |
| SCHEMBL17780556 | 0.95 | VRK1 (0.37) | BRD4TAF1PARP1MAPK7VRK1 | |
| SCHEMBL17780536 | 0.94 | VRK1 (0.36) | BRD4TAF1PARP1VRK1 | |
| SCHEMBL17780382 | 0.93 | VRK1 (0.36) | BRD4TAF1PARP1VRK1 | |
| SCHEMBL16178583 | 0.93 | VRK1 (0.36) | BRD4TAF1PARP1VRK1 | |
| SCHEMBL17780301 | 0.93 | VRK1 (0.36) | BRD4TAF1PARP1VRK1MARK3 | |
| SCHEMBL14952337 | 0.93 | BRD4 (0.36) | BRD4TAF1PARP1VRK1PLK1 | |
| SCHEMBL16186412 | 0.93 | BRD4 (0.36) | BRD4TAF1PARP1VRK1PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9351974-B2 | Substituted pteridinones for the treatment of cancer | OSI Pharmaceuticals, LLC (US) | 2016-05-31 | — | — | US | claimed |