Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 20/20 | 0.95 |
| ▸ | ABL1 | P00519 | 2/20 | 0.62 |
| ▸ | BCR | P11274 | 2/20 | 0.62 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | DDX3X | O00571 | 1/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.62 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | ALB | P02768 | 1/20 | 0.62 |
| ▸ | RAF1 | P04049 | 1/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16365772 | 0.93 | KIT (0.95) | KITABL1BCRPDGFRAPLK4 | |
| SCHEMBL16365777 | 0.92 | KIT (0.82) | KITABL1BCRABL2 | |
| SCHEMBL16365770 | 0.89 | KIT (0.96) | KITABL1BCRPDGFRAPLK4 | |
| SCHEMBL16321597 | 0.87 | KIT (0.96) | KITABL1BCRPDGFRAPLK4 | |
| SCHEMBL17782819 | 0.85 | KIT (0.83) | KITABL1BCRPDGFRAEGFR | |
| SCHEMBL16365789 | 0.85 | KIT (0.94) | KITABL1BCR | |
| SCHEMBL16365786 | 0.84 | KIT (0.94) | KITABL1BCR | |
| SCHEMBL16321029 | 0.84 | KIT (0.92) | KITABL1BCRPDGFRAPDGFRB | |
| SCHEMBL17782781 | 0.84 | KIT (0.95) | KIT | |
| SCHEMBL16365874 | 0.82 | KIT (0.86) | KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10202370-B2 | Benzimidazole derivatives as selective proteine kinase inhibitors | AB SCIENCE (FR) | 2019-02-12 | — | — | US | claimed |
| US-20160152608-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE PROTEINE KINASE INHIBITORS | AB SCIENCE (FR) | 2016-06-02 | — | — | US | claimed |
| EP-3010906-B1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE PROTEIN KINASE INHIBITORS | AB SCIENCE (FR) | 2019-06-12 | — | — | EP | disclosed |
| EP-3010906-B1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE PROTEIN KINASE INHIBITORS | AB SCIENCE (FR) | 2019-06-12 | — | — | EP | disclosed |
| US-10202370-B2 | Benzimidazole derivatives as selective proteine kinase inhibitors | AB SCIENCE (FR) | 2019-02-12 | — | — | US | disclosed |
| US-10202370-B2 | Benzimidazole derivatives as selective proteine kinase inhibitors | AB SCIENCE (FR) | 2019-02-12 | — | — | US | disclosed |
| US-20160152608-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE PROTEINE KINASE INHIBITORS | AB SCIENCE (FR) | 2016-06-02 | — | — | US | disclosed |
| US-20160152608-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE PROTEINE KINASE INHIBITORS | AB SCIENCE (FR) | 2016-06-02 | — | — | US | disclosed |
| US-20160152608-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE PROTEINE KINASE INHIBITORS | AB SCIENCE (FR) | 2016-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202370-B2 | Benzimidazole derivatives as selective proteine kinase inhibitors | KIT, CHUK, CSNK1E | KIT 1/4885ABL1 121/4885BCR 380/4885 |
| US-20160152608-A1 | BENZIMIDAZOLE DERIVATIVES AS SELECTIVE PROTEINE KINASE INHIBITORS | KIT, CHUK, CSNK1E | KIT 1/4885ABL1 121/4885BCR 380/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.