Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.65 |
| ▸ | GPR52 | Q9Y2T5 | 8/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16446841 | 0.88 | PDE4B (0.67) | PDE4BGPR52PDE4D | |
| SCHEMBL17784210 | 0.81 | PDE4B (0.50) | PDE4B | |
| SCHEMBL17784229 | 0.81 | PDE4B (0.67) | PDE4BGPR52PDE4D | |
| SCHEMBL17784218 | 0.80 | PDE4B (0.69) | PDE4BGPR52PDE4D | |
| SCHEMBL17784214 | 0.79 | PDE4B (1.00) | PDE4BCRHR1HPGD | |
| SCHEMBL17784224 | 0.79 | PDE4B (0.38) | PDE4BPDE4DALDH1A1 | |
| SCHEMBL17784222 | 0.79 | PDE4B (0.69) | PDE4BGPR52PDE4D | |
| SCHEMBL17784215 | 0.78 | PDE4B (0.69) | PDE4BGPR52PDE4D | |
| SCHEMBL16447019 | 0.77 | PDE4B (0.82) | PDE4BPDE4DHPGD | |
| SCHEMBL17784231 | 0.77 | PDE4B (0.66) | PDE4BPDE4DALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688683-B2 | Substituted condensed pyrimidine compounds | Grünenthal GmbH (DE) | 2017-06-27 | — | — | US | disclosed |
| US-20160152624-A1 | NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS | Grünenthal GmbH (DE) | 2016-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160152624-A1 | NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS | PDE4A, PDE4B, TYMP | PDE4B 2/4885GPR52 1370/4885CRHR1 4004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.