Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 19/20 | 0.58 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17785314 | 0.93 | KLKB1 (0.65) | KLKB1FAAH | |
| SCHEMBL31339410 | 0.84 | KLKB1 (0.63) | KLKB1 | |
| SCHEMBL17785263 | 0.84 | KLKB1 (0.63) | KLKB1 | |
| SCHEMBL28379609 | 0.77 | KLKB1 (0.78) | KLKB1 | |
| SCHEMBL17786836 | 0.76 | KLKB1 (0.67) | KLKB1 | |
| SCHEMBL17786902 | 0.75 | KLKB1 (0.47) | KLKB1 | |
| SCHEMBL28279023 | 0.74 | KLKB1 (0.53) | KLKB1FAAH | |
| SCHEMBL17785285 | 0.74 | KLKB1 (1.00) | KLKB1 | |
| SCHEMBL28279003 | 0.73 | KLKB1 (0.53) | KLKB1 | |
| SCHEMBL21081704 | 0.73 | KLKB1 (0.70) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3224256-A1 | N-((HET)ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS, | Kalvista Pharmaceuticals Limited (GB) | 2017-10-04 | — | — | EP | disclosed |
| WO-2016083820-A1 | N-((HET)ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS, | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | disclosed |