SCHEMBL17786129

SCHEMBL17786129

Cc1cn(-c2ccc(C(N)=O)c(NCc3cccnc3)c2)c2c1OCC(C)(C)C2

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 5/20 0.43
HSP90AB1 P08238 2/20 0.43
ALDH1A1 P00352 6/20 0.43
MAPT P10636 5/20 0.43
KDM4E B2RXH2 4/20 0.43
GAA P10253 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CDK5 Q00535 1/20 0.41
CDK5R1 Q15078 1/20 0.41
LMNA P02545 1/20 0.41
RPS6KB1 P23443 1/20 0.41
AKT1 P31749 1/20 0.41
MKNK1 Q9BUB5 1/20 0.39
MKNK2 Q9HBH9 1/20 0.39
CDK2 P24941 2/20 0.39
CCNA2 P20248 1/20 0.39
CCNA1 P78396 1/20 0.39
POLB P06746 1/20 0.39
HPGD P15428 1/20 0.39
CCNE1 P24864 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1218738 0.87 HSP90AA1 (0.46) HSP90AA1HSP90AB1ALDH1A1MAPTKDM4E
SCHEMBL13673761 0.86 HSP90AA1 (0.43) HSP90AA1HSP90AB1ALDH1A1MAPTKDM4E
SCHEMBL3823671 0.86 HSP90AB1 (0.60) HSP90AA1HSP90AB1
SCHEMBL1220836 0.79 HSP90AA1 (0.57) HSP90AA1HSP90AB1ALDH1A1MAPTKDM4E
SCHEMBL1221076 0.77 HSP90AB1 (0.65) HSP90AA1HSP90AB1ALDH1A1MAPTKDM4E
SCHEMBL1218856 0.75 HSP90AB1 (0.64) HSP90AA1HSP90AB1
SCHEMBL19112676 0.75 CDK5 (0.42) HSP90AA1ALDH1A1MAPTKDM4EGAA
SCHEMBL1220767 0.69 HSP90AB1 (0.62) HSP90AA1HSP90AB1ALDH1A1KDM4E
SCHEMBL1220070 0.67 HSP90AB1 (0.68) HSP90AA1HSP90AB1
SCHEMBL1220468 0.67 HSP90AB1 (0.67) HSP90AA1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2380879-B1 Tetrahydroindolone and tetrahydroindazolone derivatives ESANEX INC (US) 2017-07-12 EP claimed
WO-2016086153-A2 USE OF TETRAHYDRO!NDAZOLYLBEIMZAMIDE AND TETRAHYDROINDOLYLBENZAMIDE DERIVATIVES FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) AND ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS) ESANEX, INC. (US) 2016-06-02 WO disclosed