Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 3/20 | 0.69 |
| ▸ | GPBAR1 | Q8TDU6 | 9/20 | 0.60 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.60 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.60 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.60 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.60 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.60 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.60 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.60 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.60 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | VDR | P11473 | 2/20 | 0.53 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL17786188 | 1.00 | EPHA2 (0.69) | EPHA2GPBAR1AKR1B10AKR1B1EFNA1 | |
| Iodide SCHEMBL21878954 | 1.00 | EPHA2 (0.69) | EPHA2GPBAR1AKR1B10AKR1B1EFNA1 | |
| Iodide SCHEMBL17786186 | 1.00 | EPHA2 (0.69) | EPHA2GPBAR1AKR1B10AKR1B1EFNA1 | |
| Iodide SCHEMBL17786155 | 1.00 | EPHA2 (0.69) | EPHA2GPBAR1AKR1B10AKR1B1EFNA1 | |
| Iodide SCHEMBL17786150 | 0.99 | EPHA2 (0.70) | EPHA2GPBAR1AKR1B10AKR1B1EFNA1 | |
| Iodide SCHEMBL17786149 | 0.99 | EPHA2 (0.70) | EPHA2GPBAR1AKR1B10AKR1B1EFNA1 | |
| Iodide SCHEMBL17786157 | 0.97 | EPHA2 (0.71) | EPHA2GPBAR1AKR1B10AKR1B1EFNA1 | |
| Iodide SCHEMBL17786159 | 0.97 | EPHA2 (0.71) | EPHA2GPBAR1AKR1B10AKR1B1EFNA1 | |
| Iodide SCHEMBL17786177 | 0.95 | EPHA2 (0.71) | EPHA2GPBAR1AKR1B10AKR1B1EFNA1 | |
| Iodide SCHEMBL17786176 | 0.95 | EPHA2 (0.71) | EPHA2GPBAR1AKR1B10AKR1B1EFNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11629166-B2 | Compound for treating clostridium difficile | ASTON UNIVERSITY (GB) | 2023-04-18 | — | — | US | disclosed |
| US-20200131223-A1 | COMPOUND FOR TREATING CLOSTRIDIUM DIFFICILE | INSIGHT HEALTH LIMITED | 2020-04-30 | — | — | US | disclosed |
| US-20170320906-A1 | COMPOUND FOR TREATING CLOSTRIDIUM DIFFICILE | INSIGHT HEALTH LIMITED (GB) | 2017-11-09 | — | — | US | disclosed |
| EP-3223855-A1 | COMPOUND FOR TREATING CLOSTRIDIUM DIFFICILE | Aston University (GB) | 2017-10-04 | — | — | EP | disclosed |
| WO-2016083819-A1 | COMPOUND FOR TREATING CLOSTRIDIUM DIFFICILE | ASTON UNIVERSITY (GB) | 2016-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11629166-B2 | Compound for treating clostridium difficile | DSTN, DAD1, DDOST | EPHA2 1043/4885GPBAR1 77/4885AKR1B10 2810/4885 |
| US-20170320906-A1 | COMPOUND FOR TREATING CLOSTRIDIUM DIFFICILE | DSTN, DAD1, DDOST | EPHA2 1043/4885GPBAR1 77/4885AKR1B10 2810/4885 |
| US-20200131223-A1 | COMPOUND FOR TREATING CLOSTRIDIUM DIFFICILE | DSTN, DAD1, DDOST | EPHA2 1043/4885GPBAR1 77/4885AKR1B10 2810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.