Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HMGCR | P04035 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | EP300 | Q09472 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | S100B | P04271 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17774729 | 0.85 | HTT (0.52) | HTTCYP3A4ALDH1A1HPGDHMGCR | |
| SCHEMBL6371675 | 0.85 | CYP3A4 (0.55) | HTTCYP3A4ALDH1A1LMNAKDM4E | |
| SCHEMBL3661837 | 0.84 | HTT (1.00) | HTTCYP3A4ALDH1A1MAPK1HPGD | |
| SCHEMBL30398255 | 0.84 | HTT (1.00) | HTTCYP3A4ALDH1A1MAPK1HPGD | |
| SCHEMBL31175997 | 0.82 | HTT (0.81) | HTTCYP3A4ALDH1A1MAPK1HPGD | |
| SCHEMBL14780513 | 0.82 | HTT (0.81) | HTTCYP3A4ALDH1A1MAPK1HPGD | |
| SCHEMBL26027709 | 0.81 | KDM4E (0.56) | HTTCYP3A4ALDH1A1LMNAKDM4E | |
| SCHEMBL22222472 | 0.80 | HTT (0.46) | HTTCYP3A4ALDH1A1MAPK1LMNA | |
| SCHEMBL5526244 | 0.80 | HTT (0.52) | HTTCYP3A4ALDH1A1MAPK1HPGD | |
| SCHEMBL1545430 | 0.79 | HTT (0.81) | HTTCYP3A4ALDH1A1MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083490-A1 | COMPOUNDS FOR THE TREATMENT OF AMYLOID-ASSOCIATED DISEASES | REMYND NV (BE) | 2016-06-02 | — | — | WO | disclosed |