Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.76 |
| ▸ | MEN1 | O00255 | 5/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.76 |
| ▸ | CASP1 | P29466 | 4/20 | 0.76 |
| ▸ | CASP7 | P55210 | 4/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | TP53 | P04637 | 7/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.67 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.65 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17786563 | 0.88 | MAPT (0.76) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL5138212 | 0.86 | MAPT (1.00) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL30667444 | 0.86 | MAPT (1.00) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL4648874 | 0.86 | ABCG2 (0.82) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL17786386 | 0.86 | ABCB1 (0.76) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL25235022 | 0.86 | ABCB1 (0.79) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL30397364 | 0.86 | ABCB1 (0.79) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL30667420 | 0.85 | MAPT (0.76) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL1422017 | 0.85 | MAPT (0.76) | MAPTKDM4ECYP3A4MEN1KMT2A | |
| SCHEMBL17786466 | 0.85 | CSNK2A2 (0.75) | MAPTKDM4ECYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083490-A1 | COMPOUNDS FOR THE TREATMENT OF AMYLOID-ASSOCIATED DISEASES | REMYND NV (BE) | 2016-06-02 | — | — | WO | disclosed |