Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 20/20 | 0.65 |
| ▸ | KLK1 | P06870 | 1/20 | 0.54 |
| ▸ | F11 | P03951 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17786984 | 0.86 | KLKB1 (0.72) | KLKB1F11 | |
| SCHEMBL17786946 | 0.83 | KLKB1 (0.65) | KLKB1KLK1F11 | |
| SCHEMBL17786882 | 0.79 | KLKB1 (0.68) | KLKB1KLK1F11 | |
| SCHEMBL18544555 | 0.79 | KLKB1 (0.80) | KLKB1KLK1F11 | |
| SCHEMBL19471912 | 0.79 | KLKB1 (1.00) | KLKB1 | |
| SCHEMBL17786904 | 0.79 | KLKB1 (0.72) | KLKB1F11 | |
| SCHEMBL17786814 | 0.78 | KLKB1 (0.64) | KLKB1 | |
| SCHEMBL17693890 | 0.77 | KLKB1 (1.00) | KLKB1 | |
| SCHEMBL16246724 | 0.76 | KLKB1 (0.63) | KLKB1KLK1F11 | |
| SCHEMBL31339412 | 0.76 | KLKB1 (0.63) | KLKB1KLK1F11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | claimed |
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | disclosed |