Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 20/20 | 0.62 |
| ▸ | F11 | P03951 | 2/20 | 0.59 |
| ▸ | KLK1 | P06870 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17786947 | 0.87 | KLKB1 (0.62) | KLKB1F11KLK1 | |
| SCHEMBL16880481 | 0.78 | KLKB1 (0.49) | KLKB1KLK1 | |
| SCHEMBL17786930 | 0.77 | KLKB1 (0.70) | KLKB1 | |
| SCHEMBL17785340 | 0.76 | KLKB1 (1.00) | KLKB1F11KLK1 | |
| SCHEMBL17784761 | 0.75 | KLKB1 (0.73) | KLKB1F11KLK1 | |
| SCHEMBL19471926 | 0.75 | KLKB1 (1.00) | KLKB1F11KLK1 | |
| SCHEMBL19668274 | 0.75 | KLKB1 (1.00) | KLKB1F11KLK1 | |
| SCHEMBL17785318 | 0.75 | KLKB1 (1.00) | KLKB1F11 | |
| SCHEMBL29835875 | 0.75 | KLKB1 (1.00) | KLKB1F11 | |
| SCHEMBL17784819 | 0.74 | KLKB1 (1.00) | KLKB1F11KLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | claimed |
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | disclosed |