Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 14/20 | 0.44 |
| ▸ | KLK1 | P06870 | 6/20 | 0.43 |
| ▸ | F11 | P03951 | 2/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17787194 | 0.91 | KLKB1 (0.43) | KLKB1KLK1F11CACNA1HCACNA1G | |
| SCHEMBL17787163 | 0.89 | KLKB1 (0.48) | KLKB1KLK1F11 | |
| SCHEMBL17787125 | 0.87 | KLKB1 (0.45) | KLKB1KLK1F11 | |
| SCHEMBL17787027 | 0.86 | KLKB1 (0.44) | KLKB1KLK1F11CACNA1HCACNA1G | |
| SCHEMBL17786992 | 0.83 | KLKB1 (0.60) | KLKB1F11 | |
| SCHEMBL17786912 | 0.82 | KLKB1 (0.46) | KLKB1KLK1F11 | |
| SCHEMBL17787082 | 0.82 | KLKB1 (0.52) | KLKB1KLK1 | |
| SCHEMBL17787218 | 0.82 | KLKB1 (0.42) | KLKB1KLK1F11CACNA1HRET | |
| SCHEMBL17787140 | 0.82 | KLKB1 (0.46) | KLKB1KLK1F11CACNA1HCACNA1G | |
| SCHEMBL17786911 | 0.81 | KLKB1 (0.47) | KLKB1KLK1F11CACNA1HCACNA1G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | claimed |
| WO-2016083816-A1 | N-((HETEROARYLMETHYL)-HETEROARYL-CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2016-06-02 | — | — | WO | disclosed |