Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17787690 | 1.00 | ALK (0.41) | ALKPRMT5WDR77FGFR3NPC1 | |
| SCHEMBL12662584 | 1.00 | ALK (0.41) | ALKPRMT5WDR77FGFR3NPC1 | |
| SCHEMBL12662319 | 0.91 | ALK (0.42) | ALKPRMT5WDR77FGFR3NPC1 | |
| SCHEMBL12662229 | 0.91 | ALK (0.42) | ALKPRMT5WDR77FGFR3NPC1 | |
| SCHEMBL12662699 | 0.89 | ALK (0.41) | ALKPRMT5WDR77FGFR3NPC1 | |
| SCHEMBL17787707 | 0.89 | ALK (0.41) | ALKPRMT5WDR77FGFR3NPC1 | |
| SCHEMBL12662718 | 0.89 | ALK (0.41) | ALKPRMT5WDR77FGFR3NPC1 | |
| SCHEMBL12662565 | 0.89 | ALK (0.41) | ALKPRMT5WDR77FGFR3NPC1 | |
| SCHEMBL12662570 | 0.89 | ALK (0.41) | ALKPRMT5WDR77FGFR3NPC1 | |
| SCHEMBL12662655 | 0.88 | ALK (0.40) | ALKPRMT5WDR77FGFR3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2315763-B1 | BENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2016-06-01 | — | — | EP | disclosed |